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Product Description

A supplement with high-potency fermented wheat extract (IP-PA1) combined with synergistic nutrients including Vitamin C and Beta-glucan. SHIRUTO is uniquely formulated to help support, sustain and maintain a healthy immune system. The fermentation and extraction processes for the IP-PA1 used in SHIRUTO are internationally patented, providing an assurance of its outstanding quality.

RP SGD 113.00B0600003

GMP Certified

Complies to high standards of manufacturing

HALAL Certified

Natural Botanical Ingredients

Suitable for vegetarians

Imported from Japan

Notable Ingredients:

Fermented Wheat Extract (IP-PA1) – An ingredient that helps support overall immune health.

Vitamin C and Beta Glucan – To provide synergistic effects for immune health maintenance.



  • Supports immune system for healthy growth


  • Supports a healthy immune system


  • Supports overall immunity throughout the golden years

Discovery of IP-PA1 and its health benefits: Milestones

Discovery of IP-PA1 and its health benefits: Milestones

The FIRST and ONLY Ingredient Recognised by the CIITRA in Japan

Natural Immune Ingredient


Honorary Professor Den'ichi Mizuno of Tokyo University started the project on the function of macrophages in maintaining health. Professor Gen-Ichiro Soma and Professor Hiroyuki Inagawa joined in the project.

The macrophage activator found in wheat was discovered to be IP-PA1

Research on the prevention and improvement of various diseases through oral ingestion of IP-PA1.


Published about the effects of IP-PA1 on atopic dermatitis, improvement of hyperlipidaemia, prevention of gastric ulcer and decreasing of LDL cholesterol.

Dr. Charles Janeway in the US discovered IP-PA1 receptors that appeared in macrophages. As a result, the macrophage activation mechanism of IP-PA1 was revealed and research on natural immunity progressed dramatically. In 2011, three researchers who contributed to the clarification of natural immunity system received the Nobel Prize in Physiology and Medicine.

IP-PA1 was launched as a functional ingredient.
2010 to Present

The Innate Immunity Control Technology Research Association (certified by the Ministry of Economy, Trade and Industry of Japan) was established to conduct R&D through industry-academia cooperation for various applications of IP-PA1.

CIITRA: Control of Innate Immunity Technology Research Association
Natural Immunology Seminar Organized by CIITRA

Unique cultivation and fermentation processes have been patented in more than 10 countries

Japan, USA, Australia, Europe, Canada, China, Korea, India, Singapore, Israel, Taiwan, Russia, etc.